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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 9
First page : ( 441) Last page : ( 444)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00066.3

New UV – Spectrophotometric Method Development and Validation of Valsartan in Bulk and Pharmaceutical Dosage Forms

Gawai Mamata N1,*, Aher Smita S2, Saudager Ravindra B.3

1Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

2Department of Analytical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

3Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjeneri, Nashik-422213, Maharashtra, India

*Corresponding Author E-mail: rbs36@rediffmail.com

Online published on 30 December, 2016.

Abstract

Simple precise accurate UV Spectroscopic method has been developed and validated for estimation of valsartan in bulk and pharmaceutical dosage form. It is approved for the treatment of hypertension. It is an angiotensin II receptor antagonist. UV Spectroscopic method which is based on measurement of absorption of UV light, the spectra of valsartan in Phosphate buffer PH 7.4 showed maximum wavelength at 250 nm and calibration curve were plotted over the concentrations ranging from 2–20μg/ml of valsartan with correlation coefficient 0.9996 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.1229 and 0.3725 respectively by simple UV Spectroscopy. The proposed method was validated.

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Keywords

Valsartan, Phosphate buffer PH 7.4, spectrophotometry and validation.

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