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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 2
First page : ( 89) Last page : ( 98)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00017.1

Synthesis, Characterization and Biological Evaluation of Benzo[b][1, 2, 4]triazolo [4, 3-d][1, 4]diazepine Derivatives

Prabhakar V.1,*, Vani C. Divya2, Govindu G.1

1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India

2Department of Chemistry, Sri Padmavati Women's Degree and PG College, Tirupati, Andhra Pradesh, India

*Corresponding Author E-mail: virupakshi.prabhakar@gmail.com

Online published on 29 March, 2016.

Abstract

Heterocyclic compounds occur widely in nature and quite a few of these are essential to life processes. The literature on heterocyclic compounds is replete with examples of a large number of synthetic methods of naturally occurring systems which are pharmacologically active. The heterocyclic compounds containing nitrogen has expanded exponentially in the past decades due to their unique physical properties, specific chemical reactivity and their remarkable potential biological activities. A survey of literature on the nitrogen heterocyclic reveal that dia zepines are important constituents of a wide variety of natural products with pharmacodynamic application. The Structures of the Synthesized Compounds are Confirmed by IR, 1H NMR and 13C NMR Spectral data, Elemental Analysis, Mass spectral data. The compounds are also evaluated for their anti Oxidant activity by DPPH method, among them 13e and 13d are found as potent activity. The reaction proceeds efficiently under ambient conditions with good-to-excellent yields.

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Keywords

Benzo diazepines, synthesis, Anti oxidant Activity, Biological importance, DPPH.

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