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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 11
First page : ( 561) Last page : ( 565)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00076.6

Forced degradation study of terbinafine HCl by HPLC with PDA detector

Rao Tentu Nageswara1,*, Avuthu Muralidhar Reddy2, Reddy B. Venkata3, Murthy SNVS4

1Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India

2Department of Chemistry, SVKP & Dr. K.S Raju Arts & Science College, Penugonda, A.P, India

3Department of Animal Science, Chonbuk National University, Jeonju, South Korea

4Department of Chemistry, DLR PG College, G. Mamidada, Andhra Pradesh, India

*Corresponding Author E-mail: tentu6581@rediffmail.com

Online published on 9 March, 2017.

Abstract

A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Terbinafine HCl and related impurities. The chromatographic separations were achieved on (150×4.6 mm), 5.0 μm make: YMC-Pack ODS-AM, 120A column employing Acetonitrile: methanol and Water pH 7.5, in the ratio of 20:10:10 v/v/v as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The detector wavelength of 230 nm was employed.

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Keywords

Forced degradation, HPLC, Method validation, Terbinafine.

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