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Asian Journal of Research in Chemistry
Year : 2016, Volume : 9, Issue : 10
First page : ( 475) Last page : ( 4778)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2016.00071.7

Validation of Oxolamine Citrate by derivative UV Spectrophotometric Method in Pharmaceutical Dosage Form

Rajan V. Rele*

Central Research Laaboratory, D.G. Ruparel College, Matunga, Mumbai, 400016

*Correesponding Author E-mail: drvinraj@gmail.com

Online published on 30 December, 2016.

Abstract

A simple and precise third order derivative method have been developed and validated for the estimation of oxolamine citrate in bulk and its tablet formulation. Oxolamine citrate was estimated at 254.6 nm for the third order derivative UV-spectrophotometric method. Beer's law was obeyed in the concentration range of 1 to 14 μg/ml with coefficient of correlation value 0.9995 for third order derivative method. The method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was as 2.0487% for the above method. The proposed method was successfully applied for the determination of oxolamine citrate in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments.

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Keywords

Oxolamine citrate, Third order derivative spectroscopy.

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