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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 7
First page : ( 441) Last page : ( 444)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00070.X

Comparative evaluation of marketed formulations of Metformin HCl. available in India

Daharwal S. J.1,*, Rao S Prakash2, Singh Vijay Kumar2, Dwivedi Chandraprakash2, Singh Veena D.1

1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

2Columbia Institute of Pharmacy, Tekari, Near Vidhan sabha, Raipur, C.G., 493111, India

*Corresponding Author E-mail: daharwalresearch@rediffmail.com

Online published on 17 October, 2015.

Abstract

Metformin HCl is an oral Anti-diabetic drug belongs to the class of biguanide derivatives commonly used to treat type 2 diabetes mellitus. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of mechanical strength, dissolution study in buffer solution, content and weight uniformity between the commercially available conventional and modified (sustained release) tablets of different brand of Metformin in India. It can be concluded that standard quality control parameters always should be maintained not only for Metformin but also for all kinds of medicine for getting better drug products.

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Keywords

Metformin HCl, comparative, quality control parameters, evaluation.

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