(34.239.160.86)
Users online: 2718    [ij] [ij] [ij] 
Email id
 

Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 4
First page : ( 267) Last page : ( 272)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00046.2

Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone

Venkanna G.1,2, Madhusudhan G.1,*, Mukkanti K.2, Babu K. Chandra1, Venkateswarlu P.1

1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad-500 076, India

2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India

*Corresponding Author E-mail: madhusudhan.gutta@yahoo.com

Online published on 25 June, 2015.

Abstract

Racemic 3-Subsituted phenyl-3-(dimethylamino)-2-methylpropan-1-one resolved by means of a dynamic diastereomeric salt formation using di-Benzyl-L-tartaric acid with PTSA. The salts are formed in excellent yields and diastereomeric excesses.

Top

Keywords

Tapentadol Hydrochloride, centrally acting analgesic, Dynamic resolution, Atom aconomy, asymmetric synthesis.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
514,616,511 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.