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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 4
First page : ( 267) Last page : ( 272)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00046.2

Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone

Venkanna G.1,2, Madhusudhan G.1,*, Mukkanti K.2, Babu K. Chandra1, Venkateswarlu P.1

1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad-500 076, India

2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India

*Corresponding Author E-mail: madhusudhan.gutta@yahoo.com

Online published on 25 June, 2015.


Racemic 3-Subsituted phenyl-3-(dimethylamino)-2-methylpropan-1-one resolved by means of a dynamic diastereomeric salt formation using di-Benzyl-L-tartaric acid with PTSA. The salts are formed in excellent yields and diastereomeric excesses.



Tapentadol Hydrochloride, centrally acting analgesic, Dynamic resolution, Atom aconomy, asymmetric synthesis.


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