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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 3
First page : ( 179) Last page : ( 182)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00032.2

TBAHS Catalyzed Synthesis of β-Acetamido Ketones/Esters

Kotra Narasimha Murthy1,*, Reguri Buchi Reddy2, Khagga Mukkanti

1Center for Chemical Science and Technology, JNT University, Kukatpally, Hyderabad

2PCA Laboratories Ltd, Kandivali, Industrial Estate, Mumbai, India

*Corresponding Author E-mail: kotramurthy@hotmail.com

Online published on 2 May, 2015.

Abstract

An alternative synthesis of amidoalkyl naphthols, employing a four-component reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile to form the corresponding β-acetylamino ketones at room temperature in the presence of a catalytic amount of tetrabutyl ammonium hydrogen sulphate (TBAHS) has been described. The present procedure offers advantages such as shorter reaction time, simple workup with excellent yields. This simple procedure combined with the easy recovery and reuse of the catalyst makes this method economic, benign and a greener chemical process for the synthesis of β-acetamido ketones.

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Keywords

Phase transfer catalyst, one-pot reaction, β-acetylamino ketones, short reaction times.

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