TBAHS Catalyzed Synthesis of β-Acetamido Ketones/Esters Kotra Narasimha Murthy1,*, Reguri Buchi Reddy2, Khagga Mukkanti 1Center for Chemical Science and Technology, JNT University, Kukatpally, Hyderabad 2PCA Laboratories Ltd, Kandivali, Industrial Estate, Mumbai, India *Corresponding Author E-mail: kotramurthy@hotmail.com
Online published on 2 May, 2015. Abstract An alternative synthesis of amidoalkyl naphthols, employing a four-component reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile to form the corresponding β-acetylamino ketones at room temperature in the presence of a catalytic amount of tetrabutyl ammonium hydrogen sulphate (TBAHS) has been described. The present procedure offers advantages such as shorter reaction time, simple workup with excellent yields. This simple procedure combined with the easy recovery and reuse of the catalyst makes this method economic, benign and a greener chemical process for the synthesis of β-acetamido ketones. Top Keywords Phase transfer catalyst, one-pot reaction, β-acetylamino ketones, short reaction times. Top |