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Asian Journal of Research in Chemistry
Year : 2015, Volume : 8, Issue : 12
First page : ( 739) Last page : ( 744)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2015.00119.4

Visible Spectrophotometric Estimation of Aripiprazole

Majhi Somyadeep1, Patro Saroj Kumar1,*, Kumar P. Sudhir2

1Department of Pharmaceutical Analysis and Quality Assurance, Institute of Pharmacy and Technology, Salipur, Cuttack, Orissa-754202

2School of Phrmceutical Sciences, Siksha "O" Anusndhan University, Bhubaneswar

*Corresponding Author E-mail: skpatro69@gmail.com

Online published on 29 January, 2016.

Abstract

Three new, simple, sensitive and economical methods (Method I, II and III) were developed for the determination of aripiprazole in pure and pharmaceutical formulation. Method-1 is based on the formation of condensed product obtained when Aripiprazole in acidic conditions reacted with 2, 4-dinitrophenylhydrazine in methanol to form yellowish orange chromogen (hydrazone formation) exhibiting λ max at 480nm. Method-II is based on the formation of Yellow colored chromogen (formation of chalcone) by reacting with vanillin in the presence of sulphuric acid medium exhibiting λ max at 5 60nm. Method-III is based on the formation of dark yellow colored chromogen (cyclic chalcone) by reacting with Cinamaldehyde in the presence of nitric acid exhibiting λ max at 580nm. These methods obeyed Beer'slaw in the concentration range of 2.5–40μg/ml, 2–9 μg/ml and 2.5–15 μg/ml respectively. The results of analysis for the three methods were validated statistically and by recovery studies. The colored chromogens formed are stable for more than 8 hours in all the three methods. The results obtained with the proposed methods are in good agreement with labeled amounts when marketed pharmaceutical preparations are analyzed.

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Keywords

Visible Spectrophotometry, Aripiprazole, Tablet analysis.

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