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Asian Journal of Research In Chemistry
Year : 2014, Volume : 7, Issue : 6
First page : ( 596) Last page : ( 599)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Development and Validation of UV Spectrophotometric Method of Amlodipine Besylste in Bulk and Pharmaceutical Formulation

Babu G. Raveendra1,*, Kumar J. Praveen2, Surekha P. Sri Lakshmi1, Praveen T. Kala1, Rao P. Sambhasiva3

1Department of Pharmaceutical Analysis, D.C.R.M. Pharmacy College, Inkollu-523167

2Analytical Research and Development, Laurus Labs Private Limited, Hyderabad-500082

3Department of Pharmaceutics, Vijaya College Pharmacy, Hayathnagar, Hyderabad-501511

*Corresponding Author E-mail: g_raveendra@yahoo.com

Online published on 28 August, 2014.

Abstract

A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Amlodipine besylate in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 365nm. The percentage recovery of Amlodipine besylate ranged from (99.80 ± 1.09) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5–25μg/ml having line equation y = Y=0.0163C - 0.00120 with correlation coefficient of 0.9999. Results of the analysis were validated statistically and by recovery study.

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Keywords

Amlodipine besylate, UV Spectrophotometry, Validation, Beer's law.

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