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Asian Journal of Research In Chemistry
Year : 2012, Volume : 5, Issue : 12
First page : ( 1437) Last page : ( 1439)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Nootropic activity of Ocimum gratissimum in Streptozotocin induced Amnesia

Thalla Sreenu1,*, Tammu Jyothibasu1, Thalla Subba Reddy2

1Department of Pharmacology, A.S.N Pharmacy College, Tenali, Andhra Pradesh, India

2Department of biotechnology, S.K. University, Ananthapur, Andhra Pradesh, India

*Corresponding Author E-mail: sreenuthalla87@gmail.com

Online published on 7 February, 2013.

Abstract

Male Swiss albino mice weighing about 25-30g were taken and amnesia was induced by injecting Streptozotocin (STZ) on 1 and 3 days (3mg/kg) bilaterally. After 5 days of injection the animals were treated with 100mg/kg and 200mg/kg (p.o) of Ocimum gratissimum (OG) extract for 2 weeks. Various behavioural parameters like Elevated plus Maze, Passive shock avoidance, Y-Maze tests were performed. Ocimum gratissimum improved learning and memory of mice as indicated by decreased transfer latency, increased step-down latency and increase in percentage alteration. Ocimum gratissimum extract has shown decreased levels of Acetylcholine esterase enzyme. The methanolic extract of the plant possessed anti-amnesic property at a dose level.

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Keywords

Nootropic, Streptozotocin, Ocimum gratissimum.

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