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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 2
First page : ( 82) Last page : ( 84)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00017.6

A Validated Non-aqueous Potentiometric Titration Method for Quantitative Determination of Terbutaline Sulphate from Pharmaceutical Preparation

Rajan V Rele*, Prathamesh P Tiwatane

Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai, 400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 7 April, 2020.


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of terbutaline sulphate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 50% to 150% of 0.400 mg of drug substance weight. The percentage recovery of terbutaline sulphate in the optimized method was between 99.39 to 99.64%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.



Terbutaline sulphate, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid mercury acetate.


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