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Asian Journal of Research in Chemistry
Year : 2020, Volume : 13, Issue : 1
First page : ( 19) Last page : ( 22)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2020.00005.X

Pharmacological Screening of Rhizome of Curcuma amada roxb. in Rodent models

Vishwakarma Manish*, Chourasia Anand

Millennium College of Pharmacy, Bhopal-462001

*Corresponding Author E-mail: vishvkarmamanish51@gmail.com

Online published on 7 April, 2020.

Abstract

This is the first report to screen scientifically an anticonvulsant effect of hydroalcoholic extract of Curcuma amada in different animal models. The results revealed that treatment with hydroalcoholic extract of Curcuma amada protected against MES and PTZ-induced convulsions and mortality, and these effects were comparable with standard anticonvulsant agents. In order to evaluate the therapeutic value of hydroalcoholic extract as anticonvulsant, we tested its influence in different animal models viz., PTZ and MES-induced seizures in Swiss albino mice. In MES induced seizure model, hydroalcoholic extract of Curcuma amada dose dependently decreased duration of hind limb extension that was comparable to that of diazepam. The mechanism by which hydroalcoholic extract of Curcuma amada produced anticonvulsant effect against MES-induced seizures is not known. We also tested the effects of hydroalcoholic extract of Curcuma amada against convulsions induced by PTZ, an agent widely reported to induce convulsion by inhibition and/or attenuation of GABA-ergic neurotransmission.

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Keywords

Curcuma amada, Anti-convulsion, PTZ, GABA, Rodent Models.

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