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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 4
First page : ( 225) Last page : ( 230)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00043.9

High Performance Liquid Chromatography-Inductively coupled plasma Mass Spectrometry

Dr. Sri Bhavya*, Fatima Amina, Swethasri R., Dr. Sumakanth M

Department of Pharmaceutical Analysis, RBVRR Women's College of Pharmacy, Barkatpura, Hyderabad, India

*Corresponding Author E-mail: bhavya.khagga@gmail.com

Online published on 19 December, 2019.

Abstract

Speciation analysis has evolved into an valuable tool in human health risk evaluation, environmental survey and food quality control. The eventual impact of an element will be dictated by particular species of forms of the element, rather than its total concentration. Separation and detection of species of several elements in single analytical run can be accomplished by high performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry (HPLC/ICP-MS). Although various methods are available for speciation analysis. Yet, because of several advantages like versatility, robustness, sensitivity, and multielement capabilities HPLC-ICP-MS has become the most popular technique for element specific speciation studies. This review will focus on fundamentals of HPLC/ICP-MS, recent advancements and its recent applications in various fields.

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Keywords

Speciation, robustness, sensitivity, advancements, applications.

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