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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 2
First page : ( 63) Last page : ( 68)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00014.2

Microwave Assisted Synthesis, Characterization and Antibacterial Study of Some Novel Schiff's Bases and Azetidinone Compounds derived from Ibuprofen

Al-Hazam Hanan A.1, Al-Mosawi Suha K.2, Al-Shamkhani Zeki A. Naser1,*

1Department of Chemistry, College of Science, University of Basrah, Basrah-Iraq

2Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Basrah-Iraq

*Corresponding Author E-mail: alshamkhani.zeki74@gmail.com

Online published on 15 May, 2019.

Abstract

This work involves synthesis of some new heterocyclic compounds including azetidinone compounds. The new Schiff bases derived from ibuprofen, which was synthesized by microwave irradiation of ibuprofen with hydrazine hydrate in absolute ethanol and this amino compound condensation with different aromatic aldehydes in absolute ethanol. Azetidinone compounds were synthesized by cycloaddition reaction of chloroacetyl chloride to imine group of Schiff bases in dry benzene. M.P., TLC, CHN, UV, FTIR and NMR spectroscopy has characterized all the synthesized compounds. The biological screening data of the synthesized compounds were also studied.

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Keywords

Schiff bases, Azetidinone, Antibacterial.

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