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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 2
First page : ( 55) Last page : ( 57)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00012.9

An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme

Gokavarapu Kishore1,*, Devkar Rahul Uttamrao1, Gokavarapu Sarita3, Samala Shiva Rama Krishna2, Rao Durga Prasad3

1Production Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

2Research and Development Department, Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

3QC and ADL Department-Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

*Corresponding Author E-mail: g.kishore@live.com

Online published on 15 May, 2019.

Abstract

The present paper describes the CAL-B (Enzymatic) Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70–75% overall yield.

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Keywords

Pregabalin, CAL-B, Enantioselective, Enzyme, Hydrolysis.

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