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Asian Journal of Research in Chemistry
Year : 2019, Volume : 12, Issue : 2
First page : ( 49) Last page : ( 54)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2019.00011.7

Novel Curcumin Derivatives: Targeted for Anti-Inflammatory Activity

Prafulla Sabale1,*, Lata Potey1, Priya Rahangdale1, Vidya Sabale2

1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033, M.S

2Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440027, M.S

*Corresponding Author E-mail: prafullasable@rediffmail.com

Online published on 15 May, 2019.

Abstract

Curcuminwhich is commonly used as a spice is also well documented as the golden nutraceutical which is chemically called as diferuloylmethane. Numerous studies have indicated that curcumin is a highly potent antimicrobial agent and has been shown to be active against various chronic diseases including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases. Recently the study has been reported thatthe curcumin also act as an Anti-inflammatory agent by the inhibition of eicosanoids generating enzyme including phospholipase A2, cyclooxygenases and lipoxygenases. In this article we have reported the synthesis and evaluation of novel curcumin derivatives (1, 7-bis(4-(3-substituted) benzoyloxy-3 mthoxyphenyl)hepta-1, 6-diene-3, 5-dione) asanti-inflammatory agents. The chemical structures of the synthesized compounds were verified on the basis of spectral data and elemental analysis. In vitroAntiinflammatory activity was determined by using Plethysmometer with Paw volume method by using Celecoxib as standard. The molecular docking studies were also carried out by V Life MDS software into the active site of COX-2 enzymes (PDB ID: 3NL1). The compounds 2g and 2j haveshown to be good anti-inflammatory agent with highest docking scores with-4.0083, -3.9576 and 54.61%, 50.46% inhibition respectively compared with 53.46% inhibition of standard Celecoxib. The anti-inflammatory activity and docking results highlighted the fact, that the value of curcumin as a nutraceutical can be increases through thechemical modification.

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Keywords

Curcumin, Nutraceutical, Molecular docking, Anti-inflammatory, COX-2 enzyme.

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