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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 5
First page : ( 815) Last page : ( 818)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00144.X

A Review Article on Flash Chromatography

Sravani A*

Department of Pharmaceutical Analysis and Quality Assurance, Teegala Ram Reddy College of Pharmacy, Hyderabad

*Corresponding Author E-mail: alamsravani@gmail.com

Online published on 20 December, 2018.


Flash chromatography is a purification technique that can be elucidated as a modified preparative column chromatography. Flash chromatography is a technique obtained by the blend of medium pressure and short column chromatography, which results in quick segregation of mixture of components. The efficiency and speed of classical column chromatography can be increased by the use of high pressurized gas to pump the solvent across the column. In contrast to the many other chromatographic techniques, large samples can be separated and isolated using flash chromatography. This technique in many cases is used as an antecedent step to the highly sophisticated methods such as HPLC, NMR and FT-IR so as to obtain purified samples. The main applications of flash chromatography include refinement of synthetic products, segregation of intended compounds from natural products, isolation of purified compounds for further sophisticated analysis and the segregation of complex blend of mixtures into simpler fractions for analysis. The present review focuses on the different aspects of flash chromatographic technique.



Flash chromatography, fractional collectors, preparative chromatography, purification technique, high pressurized gas.


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