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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 5
First page : ( 806) Last page : ( 810)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00142.6

Modified reaction condition to achieve high yield and cost efficient hazardous free synthesis of Sorafenib API

Samala Shiva Rama Krishna1,*, Rao B Srinivasa2, Gokavarapu Kishore2, Gokavarapu Sarita3, Gandhi Sunil4

1Research and Development Department, Helios Lifesciences Limited, Industrial Growth Center, 79 and 100 Malanpur, District: Bhind, MP-477117

2Production Department, Helios Lifesciences Limited, Industrial Growth Center, 79 and 100 Malanpur, District: Bhind, MP-477117

3QC and ADL Department, Helios Lifesciences Limited, Industrial Growth Center, 79 and 100 Malanpur, District: Bhind, MP-477117

4Chairman, Helios Lifesciences Limited, Industrial Growth Center, 79 and 100 Malanpur, District: Bhind, MP-477117

*Corresponding Author E-mail: shivarama_samala@rediffmail.com

Online published on 20 December, 2018.

Abstract

The final stage synthesis of Sorafenib API required two key intermediates i.e., methyl-3-(4aminophenoxy)benzoate (I) and 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate(II), out of these two intermediates (I) is common and (II)is isocyanate intermediate, which is highly hazardous and creates lung problems while handling, to avoid these health, safety and environment issues instead of isocyanate we have used alternate intermediates which are different types of carbamates(III-VI), using these alternate carbamates intermediates synthesized sorafenib API with good yield and purity avoiding hazardous, synthesized these carbamates and final API were characterized by spectral data by 1H NMR, 13CNMR and HRMS.

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Keywords

Sorafenib, Isocyanate, Anticancer, Carbamates.

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