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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 3
First page : ( 588) Last page : ( 592)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00105.0

Synthesis, characterization and biological evaluation of ciprofloxacin N-N donor metal complex

Sabale M Prafulla*, Bhagwat S Dhiraj, Parwe Karan

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033, M.S.

*Corresponding Author E-mail: prafullasable@yahoo.com

Online published on 21 August, 2018.

Abstract

The development of metal based drugs with promising pharmacological application and may offer unique therapeutic opportunities. The advances in inorganic chemistry provide better opportunities to use metal complexes as therapeutic agents as the mode of action of metal complexes on living organism is differing from non metals. The lipophilicity of the drug was found to increase through the formation of chelates by which drug action is significantly increased due to the effective permeability of the drug into the site of action. The fluoroquinolones are synthetic antibiotics, active against aerobic Gram (−ve) and Gram (+ve) microorganisms. Fluoroquinolones possess 3-carboxylate group and 4-keto group which are essential for formation of metal complex. Fe(III) complex of ciprofloxacin in presence of neutral bidentate ligand (N-N) donors 1, 10-Phenanthroline had been synthesized. The structure of metal complex was confirmed by physiochemical parameters and spectroscopy techniques such as Quantitative UV, Mass Spectrometry, FT-IR spectroscopy and 1H NMR spectroscopy. Through UV studies the log ε value and molar absorptivity (ε) were compared indicating the attachment of only one mole of ciprofloxacin and 1, 10-phenanthroline donor to the central Fe(III) metal ion. The stability study of complex was evaluated as per ICH guidelines and the complex was found to be a stable. Cipofloxacin complex was evaluated for its antibacterial activity against two different microorganisms (Escherichia coli and Staphylococcus aureus). Antibacterial activity of ciprofloxacin complex showed better activity as compared to ciprofloxacin alone.

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Keywords

Metal complex, Metalloantibiotics, Fluoroquinolones, Ciprofloxacin, 1, 10-Phenanthroline.

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