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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 3
First page : ( 585) Last page : ( 587)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00104.9

Methodology study and a practical, cost efficient synthesis of a 3-(2-Methyl-1-Oxo-Indan-2-Ylmethyl)-Isochromen-1-One

Krishna S. Shiva Rama1,*, Sreenivasulu R.2

1Research Scholar, Mewar University, Rajasthan, India

2Research Supervisor, Mewar University, Rajasthan, India

*Corresponding Author E-mail: shivarama_samala@rediffmail.com

Online published on 21 August, 2018.

Abstract

1-Oxo-1H-isochromene-3-carbaldehyde (1) reacts with Indan-1-one (2) to offer 4-(1-Oxo-indan-2ylidenemethyl)-isochromen-1-one (3) which on reaction with liquid ammonia produces 3-(1-Oxo-indan-2ylmethyl)-isochromen-1-one (4). Compound 4 is reduced with LDA to 3-(2-Methyl-1-oxo-indan-2-ylmethyl)isochromen-1-one (5). The structures of the compounds are confirmed by spectral data.

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Keywords

Coumarins, anticoagulant, anti-inflammatory.

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