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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 3
First page : ( 533) Last page : ( 538)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00095.0

Synthesis, characterization and investigation of anti-Oxidant activity of hydrazide-hydrazone derivatives of 2-(2-Isopropyl-5-Methyl phenoxy) acetohydrazide

Sathe Pradnya S.**, Pete Umesh D.***, Bendre Ratnamala S.*

Department of Pesticides and Agrochemicals, School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, 425 001, India

*Corresponding Author E-mail: bendrers@rediffmail.com, bendrers@gmail.com,

**ps.sathe63@gmail.com

***umeshdpete@gmail.com

Online published on 21 August, 2018.

Abstract

Hydrazide-Hydrazone derivatives containing-NHN=CH-moiety represent an immense and rapid developing field in modern medicinal chemistry. They are also used as intermediates in organic synthesis. In the present work hydrazide based Schiff bases are synthesized from naturally occurring phenolic monoterpenoid, thymol (2isopropyl-5-methyl phenol), in order to generate biologically active moieties. Series of nine (4a-i) hydrazidehydrazone derivatives (six being new compounds)) has been synthesized by reacting 2-(2-isopropyl-5-methyl phenoxy) acetohydrazide with various benzaldehydes. All the derivatives are characterized by spectroscopic techniques. 1H, 13C NMR data of these compounds permits assignments related to the existence of E and Z isomerism in seven compounds. All the derivatives are screened for their antioxidant activity by using DPPH assay.

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Keywords

Hydrazide-Hydrazone derivatives, spectral studies, E and Z isomers, Antioxidant activity.

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