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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 467) Last page : ( 471)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00085.8

Microwave assisted synthesis, spectral, bio-potential and antituberculosis activities of Co(II) complex with Isoniazid and benzoate ion

Manikandan P.*, Rajasekar K.**, Gomadurai T.***, Sathiyamoorthy B.****, Sudhakar P.*****

Department of Chemistry, Government Arts College, Ariyalur-621 713, Tamil Nadu, India

*Corresponding Author E-mail: manijayakavin@gmail.com

**yokkesh111@gmail.com

***gomadurait@gmail.com

****sathia78@yahoo.com

*****sudhakar9715@gmail.com

Online published on 2 June, 2018.

Abstract

Microwave assisted synthesis was the new strategies in Green Chemistry. The first row transition metal of Co(II) complex was synthesized with neutral bidentate Isoniazid(INH) and benzoate anionic ligands using microwave techniques. The complex was characterized by various analytical, spectral and biological studies. The structural aspects and 1: 2: 2 (metal: INH: Benzoate ion) composition of the complex were determined from elemental analysis and metal estimation. Neutral nature of the complex from molar conductance and redox properties from cyclic voltammetry studies were also find out. The magnetic moment (VSM) and electronic spectral data value of the complex confirming by its octahedral geometry. From the IR and Far-IR spectral data the complexation and coordination mode of the complex was measured. The antibacterial and antifungal activities of the pure ligand(INH) and its Co(II) complex were carried out by Agar well diffusion method using gram negative E.coli, Salmonella and gram positive Actinobacter and C.albicance (pathogenic fungal strain). The bio-potential activities indicate the complex has much more activity than the INH. The in-vitro antituberculosis activity of INH and its complex were performed using M.tuberculosis.

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Keywords

INH, Benzoate ion, Co(II) complex, Antibacterial, Antifungal, antituberculosis.

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