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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 409) Last page : ( 412)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00074.3

A Comparative study of Vilsmeier-Haack Formylation Reactions With Phenols Under Solvent Less And Solvent Conditions

Redamala Roopa1,2,*, Merugu Ramchander2, Rajanna K.C.1

1Department of Chemistry, Osmania University, Hyderabad, (A.P)-500 007, India

2Department of Chemistry and Biochemistry, Mahatma Gandhi University, Nalgonda-508254, India

*Corresponding Author E-mail: roopamgu@gmail.com

Online published on 2 June, 2018.

Abstract

The Vilsmeier-Haack reaction with phenols has been carried out under solvent free conditions and as well as solvent conditions. The reactants are taken in a mortar and grounded with a pestle for about 20 to 30 min at room temperature. The reactants are taken in a beaker and placed in microwave for about 30 secs to 1 min. The reactions afforded formyl derivatives in fairly good yields when a mixture of dimethyl formamide (DMF) and SOCl2 is used as VH reagent. Results of solvent free reactions are more superior over solution phase reactions with very good yields and far lesser reaction times.

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Keywords

Formylation, V-H reaction, Phenols, solvent less, solvent free.

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