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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 319) Last page : ( 328)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00059.7

Synthesis and Antibacterial Studies of 2-Pyrazoline based Bis Heterocycles

Babu K.*

PG and Research Department of Chemistry, Rajah Serfoji Government College (Auto), Thanjavur, Tamil Nadu, India

*Corresponding Author E-mail: kbabu.chemistry@gmail.com

Online published on 2 June, 2018.

Abstract

Here in, I have described synthesis, spectral characterization and antibacterial activities of some novel five membered bis-heterocyclic compounds comprising both 2-pyrazoline and pyrazole related moiety. The target products were obtained by applying well known reactions such as, aldol condensation, diazotization, diazocoupling and cyclisation reactions. The structures of synthesized compounds were confirmed by the help of Melting point, TLC, FT-IR, 1H-NMR and 13C-NMR spectra. The invitro antibacterial activities were examined and most of the compounds showed very good inhibition zone against selective bacteria.

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Keywords

Diazotization, Active methelene compounds, Aldol condensation, coupling reaction, Pyrazoline.

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