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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 293) Last page : ( 297)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00055.X

Statistical Analysis of Antimicrobial Data of 2-[2-(Aroyl)aroyloxy]methyl1, 3, 4 Oxadiazoles analogues Using ANOVA

Al-Ostoot Fares Hezam1,3, Vidya R.2,  Zabiulla1, Mohammed Yasser Hussein Eissa1, Jyothi Mahima1, Pallavi H.M.1, Khanum Shaukath Ara1,*

1Department of Chemistry, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, India

2Department of Statistics, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, India

3Department of Biochemistry, Faculty of Education and Science, University of Albaidha, Albaidha, Yemen

*Corresponding Author E-mail: shaukathara@yahoo.co.in

Online published on 2 June, 2018.

Abstract

Heterocyclic chemistry has become one of the most important fields of research in pharmaceutical industry due to their many fold applications. Amongst all, heterocyclic molecules containing nitrogen and oxygen (like oxadiazole ring system) have shown most potent biological activities. Microorganisms are strictly attendant with the fitness and well-being of human beings. The present treatments of bacterial and fungal infections are a bit unsatisfactory, owing to rapidly developing drug resistance and side effects. The improved of antibacterial and antifungal agents results in resistant to drugs. A series of substituted Oxadiazoles analogues 4a-jwere synthesized and screened for their antibacterial and antifungal activities to evaluate zone of inhibition. The significant effect ofin-vitroantimicrobial and antifungal activities of compounds 4a-jwere studied using one way ANOVA. It was shown that the variables 4a-j series weresignificant. Further pairwise comparison of significant differences between the variables were analyzed using Tukey HSD. The data revels that compound 4a with 2-methyl and 3chloro group in phenyl and benzoyl ring respectively, have shown excellent activity and more potent among the 4a-j series.

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Keywords

Antimicrobial, Oxadiazoles analogues, ANOVA, Tukey HSD.

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