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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 279) Last page : ( 281)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00052.4

Eco friendly synthesis of N’-Arylidene-2-((7-bromo-2-methylpyrido[2, 3-B]pyrazin-3-yl)oxy)acetohydrazides

Rajeshwari M*

Telangana University Dichpally, Nizamabad, Telangana, 503322

*Corresponding Author E-mail: rajithamadipelly@yahoo.com

Online published on 2 June, 2018.

Abstract

5-bromo 2, 3-diamino pyridine and ethylpyruvate react each other to form 7-bromo-2-methylpyrido[2, 3b]pyrazin-3-ol (1) which further reacts with ethylchloroacetate and formethyl 2-((7-bromo-2-methylpyrido[2, 3b]pyrazin-3-yl)oxy)acetate (2). Compound 2 on reaction with hydrazinehydrate gives 2-((7-bromo-2methylpyrido[2, 3-b]pyrazin-3-yl)oxy)acetohydrazide (3), which on condensation with different aldehydes produce N’-Arylidene-2-((7-bromo-2-methylpyrido[2, 3-b]pyrazin-3-yl)oxy)acetohydrazides (4a-e).

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Keywords

Heterocycles, Aldehydes, Antitumor Agents, Hydrogen Bond, Corrosion, Hormones.

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