Catalyst free Synthesis of Phenyl Hydrazones and their Biological Evaluation Suryawanshi Vikas B.1, Momin Kalimoddin I.2, Bondge Abhay S.3, Dawale Jairaj K.4,* 1Department of Chemistry, KMC College, Khopoli, Maharashtra--410203, India 2Rajarshi Shahu College, Latur, Maharashtra-413512, India 3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra-413544, India 4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH-413521, India *Corresponding Author E-mail: jairajdawale@gmail.com
Online published on 2 June, 2018. Abstract An efficient route for the synthesis of aromatic hydrazones has been developed using simple protocol in water. The synthesis was completed by using commercially available starting material. Synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. The protocol shows broad substrate scope. The phenyl hydrazine shown drug like properties and is a good starting point for further exploration in antituberculosis drug discovery. Top Keywords Benzophenone, hydrazine hydrate, green, drug, ethanol. Top |