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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 236) Last page : ( 240)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00044.5

Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin

Mathapati Sushil R.1, Suryawanshi Vikas B.2, Bondge Abhay S.3, Dawale Jairaj K.4,*

1Department of Chemistry, S. M. P. Mahavidyalaya, Murum-413605, Dist.-Osmanabad, India

2Department of Chemistry, KMC College, Khopoli, Maharashtra-410203, India

3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra-413544, India

4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH-413521, India

*Corresponding Author E-mail: amritkund_jk@rediffmail.com

Online published on 2 June, 2018.

Abstract

5, 5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to avoid the adverse effects of phenytoin, especially on the central nervous and cardiovascular systems, a small series of amine derivatives (Mannich bases) were designed containing phenytoin nucleus. For this synthesis we follow green methodology during synthesis of phenytoin from benzyl and urea.

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Keywords

Phenytoin, Mannich bases, Green methods, Benzyl.

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