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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 217) Last page : ( 220)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00041.X

Synthesis, Characterization and Antimicrobial Activity of Some new 1, 4 Diaryl-3-Methyl-6-Imino-4, 7-Dihydro-1, 3-Thiazino (5, 4-d) Pyrazoles

Yadav A.K.1, Mehdi Mazhar2,*, Fatima Tasneem3

1Prasad Inst. of Technology, Jaunpur (U.P.)

2Asst. Prof., Chemistry Dept., Shia P G College, Lucknow (U.P.)

3Asst. Prof., Chemistry Dept., Dr. A.H.R. Shia Degree College, Jaunpur (U.P.)

*Corresponding Author E-mail: drmazharmehdi@gmail.com

Online published on 2 June, 2018.

Abstract

Pyrazolones (1) react with aromatic aldehydes to give 1-aryl-3 methyl-4-arylidene pyrazol-5-ones(2).. The condensation of 4-arylidene-pyrazol-5-ones (2) with thiourea/N-phenyl thiourea in alcoholic KOH led to formation of the title compounds 1, 4-diaryl-3-methyl-6-imino-4, 7-dihydro-1, 3-thiazine (5, 4-d) pyrazoles (3). The title compounds have been screened for their antibacterial activity against S.aureus and E.coli.

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Keywords

Synthesis, Characterization, Antimicrobial Activity, new Pyrazoles.

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