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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 166) Last page : ( 170)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00034.2

Preparation and Characterization of Flurbiprofen Co-crystals By Using Factorial Design

Zalte A.G.*, Saudagar R.B.

R. G. Sapkal College of Pharmacy, Anjaneri, Nashik

*Corresponding Author E-mail: zalteamar@gmail.com

Online published on 26 March, 2018.

Abstract

Flurbiprofen is a non-steroidal anti-inflammatory BCS class II drug of low solubility and high permeability. Pharmaceutical co-crystals of Flurbiprofen were prepared with co-crystal former as benzoic acid to improve drug its physicochemical parameters. Solvent drop grinding method was found to be successful to prepare Flurbiprofen co-crystals. All new crystalline forms were characterized by IR spectroscopy, differential scanning calorimetry, and X-ray diffraction to confirm their purity and homogeneity. Co-crystals with benzoic acid showed a faster powder dissolution rate as compared with pure active pharmaceutical ingredient (API). Co-crystals of Flurbiprofen with benzoic acid showed increase in solubility by 6.68 fold as compared with pure active pharmaceutical ingredient (API). The study showed that co-crystals is an emerging alternative to modify and enhance physicochemical properties of drug to enhance their pharmaceutical properties.

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Keywords

Flurbiprofen Co-crystals, Co-crystals, Cocrystallisation, Flurbiprofen.

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