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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 159) Last page : ( 165)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00033.0

Synthesis and type-II anti-diabetic activity of Pyrrolidine-2-carbonitrile derived Ligands in SHR-STZ Animal model

Udugade Babaso V.1,*, Gawade Shivaji P.2

1Department of Medicinal Chemistry, Satara College of Pharmacy, Degaon, Satara-415004, Maharashtra, India

2Department of Pharmacology, Sahyadri College of Pharmacy, Methawade, Sangola-413307, Maharashtra, India

*Corresponding Author E-mail: swarajudugade@gmail.com

Online published on 26 March, 2018.

Abstract

We reported the synthesis and type-II anti-diabetic activity of pyrrolidine-2-carbonitrile derived ligands in SHR-STZ animal models. 3 Dimensional Quantitative Structural activity, pharmacophore, docking studies used for design of molecules, studies reveled that novel substituted cyanopyrrolidines had been promising candidate for further research. Molecules had been synthesized and evaluated for anti-diabetic activity through the use of Spontaneously Hypertensive Rat-Streptozotocin animal model. Amongst all of the synthesized compounds 1-(2(5-methylisoxazol-3-ylamino) acetyl) pyrrolidine-2-carbonitrile, 1-(2-(5-methyl-1, 2, 4-oxadiazol-3-ylamino) acetyl) pyrrolidine-2-carbonitrile and 1-(2-(1, 2, 4-thiadiazol-5-ylamino) acetyl) pyrrolidine-2-carbonitrile had been found to be strong anti-diabetic activity.

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Keywords

Design, Synthesis, Pyrrolidine-2-carbonitrile, Anti-diabetic ligands and SHR-STZ animal model.

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