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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 149) Last page : ( 152)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00031.7

Synthesis of Some Novel Chalcone containing Pyrazole Moiety

Modhavadiya V. A.*

Department of Chemistry, Shree M. M. Science college, Morbi-363642, Saurashtra University, Rajkot, Gujarat, India

*Corresponding Author E-mail: drvasta20@gmail.com

Online published on 26 March, 2018.

Abstract

Compounds having the sulphonamide group has long been used as drugs for various diseases. The biological activity of these drugs is enhanced by complexation with metal ions. Transition metal Fe (II) complex of ligand derived from sulfamethizole and substituted p-cresol have been prepared and evaluated for antimicrobial activity. The products have been characterized by elemental analysis, IR, NMR, UV-Vis spectral studies, conductivity measurements, magnetic susceptibility measurements, molecular weight determination and stepwise stability constants by PH metric method. The elemental analysis revealed that the azo dye ligand coordinated to the metal ions in 1: 2 (metal-ligand) molar ratios. The complex are non-electrolytes as confirmed by their conductivity measurements. The infrared data indicates that the ligand are coordinated with meal ions through diazo (−N=N-) nitrogen and phenolic (−OH) oxygen. The spectral data suggest distorted octahedral geometry as shown in the proposed structure.

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Keywords

Synthesis, Ligand, Metal Complex, Bioactivity, Characterization.

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