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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 139) Last page : ( 142)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00029.9

Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties

Malthum Shankaraiah1, Banothu Venkanna2, Anireddy Jaya Shree1,*

1Centre for Chemical Sciences and Technology, IST, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, Telangana State, India

2Center for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad-500085, India

*Corresponding Author E-mail: shankar.malthum@gmail.com

Online published on 26 March, 2018.

Abstract

An efficient and inexpensive approach to the synthesis of 2-substituted 1, 3, 4-oxadiazoles from arylhydrazides and orthoester is reported using catalytic PTSA. The optimized reaction is performed using catalytic PTSA in EtOH and is complete within 1 h for non aromatic orthoesters and 2–30 h for aromatic orthoesters. The reaction permits both electron releasing and electron withdrawing groups on the arylhydrazide substrate. Most products formed in high yield and require only minimal purification. The reaction proceeded smoothly and cleanly under mild reaction conditions and no side reactions were observed. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Compared with early reports, the current reactions proceed in shorter time and require less of the orthoester.

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Keywords

1, 3, 4-Oxadiazole, NSAIDs, Antibacterial, Para toluene sulphonic acid.

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