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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 126) Last page : ( 128)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00026.3

Multicomponent synthesis of 2, 6-dihydro-2, 6-diimino-4, 8-bis (methylthio) pyrimido [2, 1-b] [1, 3] thiazine-3, 7-dicarbonitrile and its derivatives

Chidrawar Anil B.*

P.G. Department of Chemistry, Degloor College, Degloor, S.R.T.M.U., Nanded, Maharashtra, India-431717

*Corresponding Author E-mail: anilchidrawar74@gmail.com

Online published on 26 March, 2018.

Abstract

Substituted derivatives of 2, 6-dihydro-2, 6-diimino-4, 8-bis (methylthio) pyrimido[2, 1-b] [1, 3] thiazine-3, 7dicarbonitrile have been prepared through One Step Multicomponent reaction by heating a mixture of bis methylthio methylene malononitrile (I), thiourea (II) independently with different heteryl amines respectively in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. All these newly synthesized compounds were screened for antibacterial activity and characterized by elemental analysis and spectral data.

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Keywords

Bis methylthio methylene malononitrile, thiourea, heteryl amines, dimethyl formamide, K2CO3.

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