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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 121) Last page : ( 125)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00025.1

Synthesis of glycosylated-1, 2, 4-thiadiazolidines as potent antimicrobial agents

Jadhao Sneha U.*, Deshmukh Shirish P.

Department of Chemistry, Shri Shivaji College, Akola-444001

*Corresponding Author E-mail: jadhaosneha2@gmail.com

Online published on 26 March, 2018.

Abstract

A series of 4-aryl-2-β-D-glycosyl-3-oxo-5-o-tolylimino-1, 2, 4-thiadiazolidines have been prepared by the interaction of 1-β-D-glycosyl-3-aryl carbamides with N-o-tolyl-S-chloro isothiocarbamoyl chloride. The newly synthesized compounds have been characterized through usual chemical transformations and IR, 1H NMR and Mass spectral studies. The polarimetric study of the title compounds have been carried out. The newly synthesized compounds were screened for their in vitro antimicrobial activities using standard cup plate method. The title compounds exhibited mild to moderate antimicrobial activities.

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Keywords

1-β-D-glycosyl-3-aryl carbamides, N-o-tolyl-S-chloro isothiocarbamoyl chloride, 4-aryl-2-βD-glycosyl-3-oxo-5-o-tolylimino-1, 2, 4-thiadiazolidines, in vitro antimicrobial activities.

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