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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 109) Last page : ( 110)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00022.6

Microwave assisted synthesis of 1, 3, 5-triazine containing [1, 8]naphthyridine derivatives

Sandhya Gandra**, Sravanthi Garepalli Ganga*

Nicholas fine Chemicals, Balanagar, Hyderabad-500018, Telangana

*Corresponding Author E-mail: raju.sravanthi@gmail.com

** gsandhyarao@gmail.com

Online published on 26 March, 2018.

Abstract

2-Cyclopropyl-[1, 8]naphthyridine-3-carboxylic acid ethyl ester (1) reacts with different aromatic aldehydes yields N-(2-Cyclopropyl-[1, 8]naphthyridine-3-carbonyl)-guanidine (2). which on further treatment with aromatic nitriles to yield 4-(2-Cyclopropyl-[1, 8]naphthyridin-3-yl)-6-phenyl-[1, 3, 5]triazin-2-ylamine (3a-e).

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Keywords

1, 8-naphthyridine, nitriles, triazine, antibacterial activity.

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