An Efficient Synthesis of 1-(1-Benzyl-1H-benzo[D]imidazol-2-yl)-3-alkylureas using Nano-γ-Fe2O3
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Nano-γ-Fe2O3 particles are considered to be attractive as catalysts for their greater reactivity, due to high surface area, recovered easily from the reaction mixture and reusable for further reaction, therefore the method being more efficient.
Compounds 1–5 are reacted with amines to give 1-(1-benzyl-1H-benzo[d]imidazol-2-yl)-3-alkylureas. The structures of the compounds were confirmed by IR, 1HNMR Spectra and elemental analysis.
Ar= Phenyl, 2-ChloroPhenyl, 3-ChloroPhenyl, 4-ChloroPhenyl, 4-MethylPhenyl; R=Phenyl
Nano-γ-Fe2O3 was applied as an efficient, green, heterogeneous and reusable catalyst at ambient temperature; some advantages of the catalyst are clean reaction, simple purification, and high yield. The antibacterial activity of all the substituted derivatives were determined against four bacteria strains such as Staphylococcus aureus, E.coli, Salmonella typhi, Bacillus subtilis. The newly prepared compounds for antibacterial activity were screened through agar-cup method. Their antibacterial activities are investigated and reported in this paper. The prepared derivatives were growth inhibitory towards all the bacteria. In the synthesized compounds some compounds showed moderate to good activity while some were found to be inactive.
Nano-γ-Fe2O3, Amine, Heterogeneous catalyst, alkylurea.