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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 75) Last page : ( 76)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00017.2

An Efficient Synthesis of 1-(1-Benzyl-1H-benzo[D]imidazol-2-yl)-3-alkylureas using Nano-γ-Fe2O3

Janardhan E.1,*, Reddy M. Maheshwar1, Reddy P. Venkat1, Kumar M. Ranadheer2, Ramu S.3

1Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad-501301, Telangana, India

2Kakatiya Institute of Technology and Science, Yerragattu, Hanamkonda, Warangal-506015, Telangana, India

3Rishitha Biosciences, North Hastinapuram, LB Nagar, Hyderabad, 500 074, Telangana, India

*Corresponding Author E-mail: janardhanphy@yahoo.com

Online published on 26 March, 2018.

Abstract

Nano-γ-Fe2O3 particles are considered to be attractive as catalysts for their greater reactivity, due to high surface area, recovered easily from the reaction mixture and reusable for further reaction, therefore the method being more efficient.

Compounds 1–5 are reacted with amines to give 1-(1-benzyl-1H-benzo[d]imidazol-2-yl)-3-alkylureas. The structures of the compounds were confirmed by IR, 1HNMR Spectra and elemental analysis.

Scheme

Ar= Phenyl, 2-ChloroPhenyl, 3-ChloroPhenyl, 4-ChloroPhenyl, 4-MethylPhenyl; R=Phenyl

Nano-γ-Fe2O3 was applied as an efficient, green, heterogeneous and reusable catalyst at ambient temperature; some advantages of the catalyst are clean reaction, simple purification, and high yield. The antibacterial activity of all the substituted derivatives were determined against four bacteria strains such as Staphylococcus aureus, E.coli, Salmonella typhi, Bacillus subtilis. The newly prepared compounds for antibacterial activity were screened through agar-cup method. Their antibacterial activities are investigated and reported in this paper. The prepared derivatives were growth inhibitory towards all the bacteria. In the synthesized compounds some compounds showed moderate to good activity while some were found to be inactive.

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Keywords

Nano-γ-Fe2O3, Amine, Heterogeneous catalyst, alkylurea.

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