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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 55) Last page : ( 60)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00012.3

Synthesis and Anti-Bacterial Activity of 1, 4-Dihydropyridine Derivatives Embedded with Chromone and Dimedone Based Hybrids

Reddy M. Upendar1,4,*, Reddy M.C. Somasekhara2, Chakravartula Venu3

1Department of Chemistry, Rayalaseema University, Kurnool-518007, AP, India

2Department of Basic Sciences, G.P.R Engineering College (Autonomous), Kurnool-518007, AP, India

3Department of chemistry, Osmania University, Hyderabad-500007, Telangana, India

4Dr. J.C.R Bio, Plot No. 79/80, Survey No-12, Chengicherla Village, Cherlapalli Phase III Industrial Park, Hyderabad-500039, Telangana State, India

*Corresponding Author E-mail: upendram2509@gmail.com

Online published on 26 March, 2018.

Abstract

1, 4-dihydropyridines (1, 4-DHPs) represent a class of compounds possessing various structural modified derivatives, particularly amongst natural products and bioactive agents. The clinically important drugs such as Nicardipine, Nifedipine, Nimodipine, Felodipine, Isradipine and Amlodipine appeared on the market with new active functional group in their main skeleton. Due to their importance in medicinal chemistry, the present paper describes the synthesis of eight new 1, 4-dihydropyridine derivatives based on the coupling of 2-amino-4Hchromen-4-one, benzaldehyde and 5-substituted dimedones. These derivatives were evaluated for antibacterial activity (at concentration of 30 μg/mL) with reference to the antibiotic drug streptomycin. The screening results revealed that compounds with R =-CH3, (−CH3)2 and-CH2-CH3 (7b, 7c and 7d) showed antibacterial good activity.

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Keywords

Anti-bacterial activity, 1, 4-dihydropyridine, Dimedone, Hantzsch, Synthesis.

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