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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 8) Last page : ( 14)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00003.2

Synthesis, Characterization and In-Vitro Antidiabetic Studies of Vanadium Complexes derived from N2O2 donor Ligands

Pawar Shashikant P.1, Patil Tryambakrao J.2, Bendre Ratnamala S.3,*

1Smt. Narmadabai Nago Chaudhari, Arts Commerce and Science College, Kusumba, Dhule, Maharashtra, India

2Jai Hind Education Trust's Z. B. Patil College, Dhule, Maharashtra, India

3School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India

*Corresponding Author E-mail: bendrers@gmail.com

Online published on 26 March, 2018.

Abstract

Trace elements are very essential for human health. Chemists have been attracted to prepare new potent inorganic pharmaceutical agents and these are used to treat chronic diseases. Vanadium complexes are used as good diagnostic tool for diabetes mellitus. The progress in the field of development in orally active antidiabetic vanadium complexes with different coordination structures using experimental diabetic animals and enzyme inhibitory action (α-amylase inhibition). In the present study we synthesized, characterized and evaluated % αamylase inhibition by vanadium complexes having tetradentate Schiff base ligands-H2L1, H2L2 and H2L3. The mole ratio for preparation of complexes is 1: 1. The synthesized vanadium complexes were characterized by sophisticated techniques and screened for antidiabetic activity by α-amylase inhibition assay. The data assigned to conclude that H2L1 shows lowest IC50 value 0.786 mg/ml while L2V shows highest IC50 value 0.626 mg/ml.

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Keywords

Chronic diseases, antidiabetic and α-amylase Inhibition.

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