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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 6
First page : ( 845) Last page : ( 851)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00141.9

Synthesis and Characterization of vital 6-aryl Purines and their Biological Evaluation

Momin Kalimoddin I.1, Bondge Abhay S.2, Surawanshi Vikas B.3, Dawale Jairaj K.4,*

1Rajarshi Shahu Mahavidhyalaya, Latur, Maharashtra-413512, India

2Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra--413544, India

3Department of Chemistry, KMC College, Khopoli, Maharashtra--410203, India

4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH, 413521, India

*Corresponding Author E-mail: amritkund_jk@rediffmail.com

Online published on 26 March, 2018.

Abstract

An efficient route has been developed for the synthesis of 6-aryl purines in water, the ecofriendly protocol allows the reaction smooth. The diverse scope of different boronic acids has shown and synthesized intermediates showed potent inhibition of Mycobacterium Tuberculosis. The synthesized derivatives characterized well by using spectroscopic techniques NMR, mass and IR analysis. This protocol allows diverse modification as well as synthesis of 6-aryl purine derivatives.

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Keywords

Purine, drug, chloropurine, boronic acids, biological activity, TB.

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