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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 6
First page : ( 739) Last page : ( 744)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00125.0

Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1-[(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones.

Waghmare Rahul A.*

Department of Chemistry, Milind College of Science, Nagsenvana, Aurangabad-431 002

*Corresponding Author E-mail: rahulwaghmare100@gmail.com

Online published on 26 March, 2018.

Abstract

One-pot multicomponent condensation carried for obtaining 5-arylidene-1-[(2-(methylsuphonyl-amino)thiazol-4-yl)-methyl]-2-thioimidazolidin-4-ones using 2-methyl suphonyl amino-4-isothiocynato methyl thiazole, glycine and aryl aldehydes in acetic acid (Scheme1). Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine with isothiocynate. Synthesized intermediates and final compounds were characterized by I.R, 1HNMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.

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Keywords

2-Amino-4-(isothiocynatomethyl) thiazole, aryl aldehyde, glycine, acetic acid, in vitro antiinflammatory activity.

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