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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 6
First page : ( 719) Last page : ( 724)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00122.5

Catalyst Free Synthesis of Imines and their Biological Evaluation.

Momin Kalimoddin I.1, Bondge Abhay S.2, Surawanshi Vikas B.3, Dawale Jairaj K.4,*

1Rajarshi Shahu Mahavidhyalaya, Latur, Maharashtra-413512, India

2Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra--413544, India

3Department of Chemistry, KMC College, Khopoli, Maharashtra--410203, India

4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH, 413521, India

*Corresponding Author E-mail: amritkund_jk@rediffmail.com

Online published on 26 March, 2018.

Abstract

An efficient route for the synthesis of aromatic imines has been developed using simple protocol at room temperature. The synthesis was completed by using commercially available starting material. Here we synthesized fourteen imines derivatives with excellent yield. Synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. The Schiff's bases shown drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.

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Keywords

Schiff's bases, imines, biological activity, aldehydes, DMF.

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