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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 5
First page : ( 669) Last page : ( 674)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00113.4

Biological Evaluation of Co (II), Ni(II), Cu(II) and Zn(II) complexes derived from Hydrazide Ligand

Devi Jai*, Batra Nisha, Malhotra Rajesh**

Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India

*Corresponding Author E-mail: jaidevi_gju@yahoo.com

** malhotra_ksrk@yahoo.co.in

Online published on 26 March, 2018.

Abstract

Co(II), Ni(II), Cu(II) and Zn(II) complexes of the type ML2 were obtained from Schiff base ligand derived from condensation of cyanoacetylhydrazine and dehydroacetic acid. The complexes have been characterized completely using various spectroscopic techniques which suggested octahedral or distorted octahedral geometry around transition metal ion with Schiff base as tridentate ligand ONO coordinated through azomethine nitrogen and oxygen atoms of hydroxyl and carbonyl group. Studies like powder X-ray diffraction, thermal analysis (TG, DSC) and ESR spectroscopy were carried out to describe the nature of compounds. Powder XRD indicated crystalline nature of complexes. On the basis of TGA/DSC, the thermal stabilities of complexes follow the order Zn(II) > Ni(II) > Cu(II) > Co (II). In vitro, biological evaluation of compounds have been carried out against pathogenic Gram positive bacteria Bacillus subtilis, Micrococcus luteus, Gram negative bacteria Pseudomonas aeruginosa, Pseudomonas mendocina and fungi Verticillum dahliae, Cladosporium herbarium, Trichophyton soudanense. The biocidal activity of the ligand on complexation to transition metal ion has been enhanced against all strains of tested organisms under similar experimental conditions.

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Keywords

Cyanoacetylhydrazine, metal complexes, X-ray diffraction, thermal analysis, antimicrobial activity.

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