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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 4
First page : ( 593) Last page : ( 596)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00099.2

Microwave assisted facile synthesis of 5-Aryl-5, 6-dihydro-1-methyl-3propyl-1H-pyrazolo [4, 3-d]pyrimidin-7(4H)-ones and docking for antiinflammatory activity

Marupati Siddhartha1, Eppakayala Laxminarayana2,*, Malothu Ramesh3, Merugu Ramchander4, Pendyala Venkat Reddy2

1Vardhaman College of Engineering, Shamshabad, Hyderabad, 500 018, Telangana, India.

2Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad-501301, Telangana, India

3Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India

4University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India

*Corresponding Author E-mail: elxnkits@yahoo.co.in

Online published on 17 October, 2017.

Abstract

5-Aryl-5, 6-dihydro-1-methyl-3-propyl-1H-pyrazolo[4, 3-d]pyrimidin-7(4H)-ones (2a-e) were synthesized by the condensation of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide with different aldehydes using microwave irradiation. All title compounds were characterized by 1H NMR and mass spectra. Molecular docking of 5cox with ligand showed that the title compound was a potent anti-inflammatory compound.

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Keywords

Synthesis, pyrazoles, pyrimidines, microwave, docking.

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