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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 4
First page : ( 582) Last page : ( 586)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00097.9

Synthesis and Molecular docking for Anti-Inflammatory and Anti Mitotic activities of (S)-(2-Methyl-4-(1-Phenyl-1h-Thieno/Furan [3, 2-C] Pyrazol-3yl) Piperazin-1-yl)(Pyridin-2-yl) Methanone

Surakanti Ramu1, Eppakayala Laxminarayana2,*, Merugu Ramchander3, Pendyala Venkat Reddy2

1Rishitha Biosciences, North Hastinapuram, LB Nagar, Hyderabad, 500 074, Telangana, India

2Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, Hyderabad, 501301, Telangana, India

3University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India

*Corresponding Author E-mail: elxnkits@yahoo.co.in

Online published on 17 October, 2017.


The synthesis of piperazine derivatives containing thiophene and oxazole is described. They were prepared from (Z)-3-bromo-N’-phenylthiophene/furan-2-carbohydrazonoyl chloride in a series of steps. All the synthetic compounds are characterized by spectral analyses. They were further analyzed for anti-inflammatory and antimitotic activity and the results are discussed.



Synthesis, anti inflammatory activity, antimitotic activity.


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