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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 4
First page : ( 577) Last page : ( 581)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00096.7

Synthesis and Evaluation of Quinazolinone Derivatives

Kavitha K*, Yahoob Nehla, Vijayakumar B, Fathima K Reshma

Grace College of Pharmacy, Kodunthirapully, Palakkad. 678004,

*Corresponding Author E-mail: kavithakrocks@gmail.com

Online published on 17 October, 2017.

Abstract

Quinazoline, a heterocyclic compound, has been extensively studied and used in certain specific biological activities. The quinazoline-4(3H)-one and its derivatives constitute an important class of fused heterocycles that are found in more than 200 naturally occurring alkaloids. With a passage of time, newer and more complex variants of the quinazolinone structures are being discovered. The stability of the quinazolinone nucleus has inspired researchers to introduce many bioactive moieties to this nucleus to create new potential medicinal agents. They exhibit broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Here in this research, we are dealing with the antimicrobial activity of various 3phenyls substituted quinazolin 4-(3H)-one.

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Keywords

Quinazolin 4-(3H)-one, hetero cyclic anilines, Anti fungal, Antibacterial.

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