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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 4
First page : ( 470) Last page : ( 476)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00076.1

Co(II), Ni(II) and Cu(II) complexes of new Mannich base of of N’-(1H benzimidazol-1-ylmethyl) Pyridine-4-Carbohydrazide: Spectral, XRD, Molecular Docking, Antioxidant and Antimicrobial Studies

Manjuraj T1, Krishnamurthy G1,*, Bodke Yadav D.2, Naik H.S. Bhojya2, Shafeeulla Mohammed1

1Department of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka, India.

2Department of Post Graduation Studies in Industrial Chemistry, Jnanasahyadri Kuvempu University, Shankaraghatta, Karnataka, India.

*Corresponding Author E-mail: gkmnaiksahyadri@gmail.com

Online published on 17 October, 2017.

Abstract

A new mannich base ligand N’-(1H-benzimidazol-1-ylmethyl) pyridine-4-carbohydrazide (BI) formed by the condensation of benzimidazole and Isoniazid (INH), the complexes of [CoCl2(BI)2], [Ni (BI)2]Cl2, and [CuCl2(BI)2] have been synthesized and characterized by elemental analysis, conductivity measurements, 1H NMR, mass, FTIR, UV-Visible, and magnetic susceptibility. The Powder XRD studies suggested that monoclinic for [CoCl2(BI)2], [CuCl2(BI)2] complexes and orthorhombic for [Ni(BI)2]Cl2 complex. The results of antioxidant activity indicating that the complexes have excellent modes of DPPH radical scavenging inhibition, the molecular docking studies were performed to evaluate the binding energy interactions by 3MNG human antioxidant protein receptor binds to selective amino acid residues with ligand (BI) and the metal complexes.

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Keywords

Benzimidazole, Isoniazid (INH), metal complexes, antioxidant activity, molecular docking.

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