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ASIAN JOURNAL OF RESEARCH IN CHEMISTRY
Year : 2017, Volume : 10, Issue : 3
First page : ( 393) Last page : ( 398)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00067.0

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents

Kumar K. Kishore, Sharma R.S.K., Babu P. Chanti, Rao M. Sreenivasa, Prasadu K. Durga, Kumar D. Ravi*

Department of Chemistry, CMJ University, Shillong-793101, India

*Corresponding Author E-mail: kishor_kumar2827@rediffmail.com

Online published on 22 September, 2017.

Abstract

Natural products possessing a spiro carbon in their molecules have proven their biological activity in agriculture and medicine. The present paper describes the synthesis, characterization of five newly synthesized Spiro-compounds characterized by means of chromatography, IR, 1H-NMR and Mass spectral analysis. The author carried in vitro anti diabetic methods like alpha amylase and alpha glucosidase methods for anti diabetic activity of tilted compounds. The investigation of anti diabetic activity revealed that the test compounds of Spiro compounds showed favorable anti diabetic activity. Among the titled compounds some were having potent antidiabetic activity.

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Keywords

Spiro heterocyclic compounds, Spectral analysis, In vitro antidiabetic activity, Alpha amylase enzyme method and alpha-glucosidase enzyme method.

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