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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 225) Last page : ( 239)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00038.4

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Kumar Arun1, Gupta Vinita2, Singh Sanchita2, Gupta Y.K.3,*

1Research Scholar, School of Applied Sciences Singhania University, Pacheri Bari, Jhunjhunu (Raj.), India

2Department of Chemistry, Agra College, Agra, U.P., India

3Head Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, India

*Corresponding Author E-mail: ykgbkbiet123@gmail.com

Online published on 17 July, 2017.

Abstract

The Chalcone is aromatic compounds that forms the central core for different necessity of biological compounds, and are prepared by Claisen-Schmidt condensation of equimolar concentrations of arylaldehydes and acetophenones which are generally base catalysed. Chalcones are considered as the precursors of flavonoids and isoflavonoids. as the precursors the precursors of flavonoids and isoflavonoids. Chemically, chalcones are 1, 3-diaryl-2-propen-1-ones in which two aromatic rings are joined by a three carbon bridge having a carbonyl moiety and α, β unsaturation. One of the most important classes of chalcones is the ring closure reactions with hydrazine, phenyl hydrazine, guanidine, urea etc. forming heterocyclic derivatives of chalcones. Both chalcones and their heterocyclic derivatives have a large number of pharmacological activities such as anti antimicrobial, antifungal, antibacterial, antioxidant, inflammatory, antitumor, anticancer, anti mitotic, anti leishmanial, antimalarial, anti tubercular, antiviral, cytotoxic, etc. In this research paper (review) the efforts have been made to show some synthesis and biological activities of chalcones and their derivatives.

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Keywords

Chalcones, Claisen-Schmidt condensation, Antimicrobial Activity, Heterocyclic Derivatives.

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