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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 174) Last page : ( 178)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00029.3

Q analysis of Montelukast sodium and Fexofenadine hydrochloride in Tablet Formulation by Derivative Spectrophotometry

Dr. Kumar P Rajeev1,*, Kumar Rekha Rajeev2

1Department of Pharmaceutics, School of Pharmacy, PRIST University, Manamai-Nallur, ECR, Near Mahabalipuram, Chennai, Tamilnadu-603102

2Department of Pharmaceutical Analysis, School of Pharmacy, PRIST University, Manamai-Nallur, ECR, Near Mahabalipuram, Chennai, Tamilnadu-603102

*Corresponding Author E-mail: rajeevmuthup@gmail.com

Online published on 17 July, 2017.

Abstract

Objective

The aim of this study is to present the simple and sensitive method for the analysis of montelukast and fexofenadine hydrochloride and apply the proposed method for the analysis of said drugs in pharmaceutical dosage forms.

Methods

Montelukast and fexofenadine hydrochloride are used in combination for management of allergy. The procedure of the first order derivative spectrophotometry allowed simultaneous determination of montelukast sodium and fexofenadine hydrochloride in fixed dose combination product.

Results

The method employed first order derivative spectroscopy for estimation of λmax by taking 10 μg/ml each of montelukast sodium and fexofenadine hydrochloride were scanned in 200–400 nm range. The absorbance values at 340 nm and 212.6 nm of the first derivative spectrum was used for the determination of montelukast and fexofenadine hydrochloride respectively without related interference.

Conclusion

This method obeyed Beer's law in the concentration range of 4–24 μg/ml for montelukast and 4–24 μg/ml for fexofenadine hydrochloride. The results of analysis have been validated statistically and recovery studies established the accuracy of the proposed method and low values of standard deviation confirmed correctness of the used method. The method was validated as per ICH guidelines.

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Keywords

Montelukast (MLKT), Fexofenadine hydrochloride (FXD), Ultraviolet Spectrophotometry, Derivative Spectrophotometry.

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